Metallothionein Gene Experts Detail Expression, Regulation
نویسندگان
چکیده
منابع مشابه
Metallothionein gene expression in brown adipose tissue.
Reduced environmental temperature triggers a range of behavioml and physiological responses to maintain body temperature. Brown adipose tissue (BAT) is a major site of thennoregulatory heat production [ 11, and during cold exposure thennogenesis in the tissue is rapidly stimulated, through the release of noradrenaline by the sympathetic nervous system. There is a substantially increased require...
متن کاملDifferential Gene-Expression of Metallothionein 1M and 1G in Response to Zinc in Sertoli TM4 Cells
Background: Zinc (Zn) as an important trace element is essential for testicular development and spermatogenesis. Molecular mechanism of Zn action in the reproductive system may be related to metal binding low-molecular weight proteins, metallothioneins (MT). Our objective was to determine the effect of Zn on two important isoforms of MT, MT1M and MT1G genes expression on testicular sertoli cell...
متن کاملExpression and regulation of a human metallothionein gene carried on an autonomously replicating shuttle vector.
A human metallothionein (MT) gene was inserted into a bovine papillomavirus (BPV) vector. The chimeric vector (pMTII-BPV) transforms rodent fibroblasts to a cadmium-resistant phenotype. The resistance is due to the high level of expression of human MT-II in those cells. The vector is maintained in the cells as a free replicating plasmid, present at about 10--15 copies per cell. Transcription of...
متن کاملRegulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tin-protoporphyrin.
Two heme analogs, cobalt- and tin-protoporphyrin (CoPP and SnPP, respectively) have been used to probe the heme-hemopexin interaction, hemopexin receptor binding, and the mechanism of regulation of heme oxygenase (HO) and metallothionein-1 (MT-1) gene expression by hemopexin. Both CoPP and SnPP are HO inhibitors and hemopexin binds SnPP (Morgan, W. T., Alam, J., Deaciuc, V., Muster, P., Tatum, ...
متن کاملThe human metallothionein gene family: structure and expression.
Metallothioneins (MTs) are encoded by a multigene family in man. We have isolated those genes and analyzed the structure of some of them. The MT-II variant is encoded by a single functional gene: MT-IIA. The MT-IIB gene is a processed pseudogene derived from a reverse transcript of MT-II mRNA. On the other hand, the MT-I class of variants are encoded by a large number of genes, arranged in tand...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1983
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0383-9a